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Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation*

Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.*

Thorne Methyl-Guard Plus® 90 Capsules

SKU: SF789
  • Various conditions and stressors can have an adverse impact on the body’s methylation cycle. Nutrient deficiencies, environmental exposures, and other aspects of a modern lifestyle can cause inefficient methylation. In addition, approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally.


    Thorne’s Methyl-Guard Plus features betaine (trimethylgycine), methylated vitamin B12 (methylcobalamin) and folate (5-MTHF), as well as the active forms of vitamins B2 and B6, for providing efficient nutritional support for the body’s methylation challenges.*


    Benefits of Thorne’s Methyl-Guard Plus:

    • Nutritional support for individuals who have MTHFR gene mutations*
    • Enhanced cellular energy production fights fatigue*
    • Helps maintain a healthy homocysteine level in the blood, which supports cardiovascular, cognitive, and bone health*
    • Promotes fat metabolism and lean body composition*
    • Supports neurotransmitter production – natural chemicals that play an important role in nervous system functions, like attention, focus, mood, and sleep*
    • Promotes liver detoxification of many substances, including hormones like estrogen*


    Why is methylation important:

    Methylation is a simple reaction where a small molecule known as a “methyl group” is transferred from one substance to another. Methylation significantly impacts many biochemical reactions in the body and plays a beneficial role in:

    • Cardiovascular health
    • Cellular energy production
    • Fat metabolism
    • Neurological function
    • DNA production
    • Liver detoxification processes
    • Eye health
    • Histamine balance


    Who can benefit from Methyl-Guard Plus:

    • Individuals with mutations to MTHFR and other genes that adversely affect methylation*
    • Aging individuals wanting to support their cardiovascular, cognitive, and metabolic health*
    • Women seeking support for estrogen metabolism and bone health*
    • Individuals wanting nutritional support for fat metabolism and maintenance of a healthy body composition*
    • Anyone with limited consumption of methylation-supportive foods like green leafy vegetables, legumes, and cruciferous vegetables


    Features of Methyl-Guard Plus:

    • Betaine, also known as trimethylglycine, is a superior methyl donor 
    • The methylated forms of vitamin B12 (methylcobalamin) and folate (5-MTHF) benefit individuals with certain gene mutations*
    • Active forms of vitamins B2 and B6 – key cofactors in methylation processes
    • B vitamins in their active, tissue-ready forms means your body gets the greatest benefit with the least additional work*
    • Robust methylation support in fewer capsules per day than Thorne’s original Methyl-Guard®
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